A brief preliminary report1 has already been made of the findings obtained in a study of pancreatic and hepatic activity in cases of diabetes mellitus. It is the purpose of this paper to present these findings in detail and, so far as our findings seem to bear on them, to comment on certain considerations in this disease.
REVIEW OF THE LITERATURE
Although the recent work of Banting2 and his collaborators has contributed an invaluable addition to our methods of treating diabetes mellitus, there still remains much to be desired in our knowledge of the actual etiology of this disease. That a deficiency of the internal secretion of the pancreas is the immediate cause of the glycosuria is incontestably proved, but the extent to which other organic functions are involved still remains a question. According to Allen,3 in most, if not in all, cases of diabetes mellitus there must have been