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Article
March 1925

PANCREATIC AND HEPATIC ACTIVITY IN DIABETES MELLITUS: THE ALTERATIONS WITH SOME OBSERVATIONS ON THE ETIOLOGY OF THE DISEASE

Author Affiliations

BOSTON

From the Medical Services of the Massachusetts General Hospital, and the New England Deaconess Hospital.

Arch Intern Med (Chic). 1925;35(3):315-336. doi:10.1001/archinte.1925.00120090028002
Abstract

A brief preliminary report1 has already been made of the findings obtained in a study of pancreatic and hepatic activity in cases of diabetes mellitus. It is the purpose of this paper to present these findings in detail and, so far as our findings seem to bear on them, to comment on certain considerations in this disease.

REVIEW OF THE LITERATURE  Although the recent work of Banting2 and his collaborators has contributed an invaluable addition to our methods of treating diabetes mellitus, there still remains much to be desired in our knowledge of the actual etiology of this disease. That a deficiency of the internal secretion of the pancreas is the immediate cause of the glycosuria is incontestably proved, but the extent to which other organic functions are involved still remains a question. According to Allen,3 in most, if not in all, cases of diabetes mellitus there must have been

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