The pathology of Bichat, more than a century ago, centered about organs and tissues and that of Virchow about cells, while that of today also concerns the contents of later morphologic units. Little is known of the great variety of complex processes and of obscure changes which occur within cells, but it is recognized that the regulation of their hydrogen ion concentration plays an important rôle in maintaining their normal activity. In contrast to the simplicity of determining the hydrogen ion concentration of the body fluids, it is perhaps impossible to determine it accurately for a part or the whole of living cells. It is a frequent assumption that cells are of the same hydrogen ion concentration as their surrounding medium. That this is not necessarily the case has been shown by Bethe,1 Warburg,2 Harvey,3 and Jacobs4 from studies made on sea urchin eggs and plant cells. Jacobs has
PEARSE HE. THE PERMEABILITY OF HUMAN BLOOD CELLS TO CARBON DIOXID AND AMMONIUM HYDROXID IN SOLUTIONS OF SAME pH. Arch Intern Med (Chic). 1925;35(3):347–356. doi:10.1001/archinte.1925.00120090060004
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.