The present investigation was undertaken to determine whether interference with the coronary circulation has any effect on the tolerance of an animal to the digitalis bodies.1
There has long been a certain hesitation to administer digitalis to patients with heart failure associated with disorders of rhythm similar to those arising from excessive digitalization. Because of the striking similarity between the cardiac disturbances resulting from diphtheria and those from large doses of digitalis, McCullough2 recommended that the drug be withheld in this disease. The existence of such disorders as premature beats, coupling, various degrees of heart block and pulsus alternans has been taken by some as a contraindication to the use of digitalis, or, at least, as an indication for especial caution in its administration. It has seemed logical to assume that the occurrence of these abnormal phenomena implied a predisposition in the heart to their development through the digitalis bodies
GOLD H. ACTION OF DIGITALIS IN THE PRESENCE OF CORONARY OBSTRUCTION: AN EXPERIMENTAL STUDY. Arch Intern Med (Chic). 1925;35(4):482–491. doi:10.1001/archinte.1925.00120100080006
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