Although there have been many experimental and clinical attempts to find a biliary antiseptic,1 so far no drug has been shown to have a sufficiently strong or constant therapeutic action in bile to afford a solution of this important problem. Surgical intervention, which hitherto has been the most satisfactory method of treatment, theoretically is not the method of choice. Aside from its own difficulties, it often fails to eliminate the infection, especially in cases in which the bile passages and liver are involved.2 Moreover, even in cases of cholelithiasis requiring surgical treatment, it would be of great value to control an accompanying infection before operation. If, therefore, a drug can be found which can be shown to be excreted by the liver, to be present in the bile in bacteriostatic or bactericidal strength, and to be of low enough toxicity to allow its safe clinical use, it would be of
HILL JH, SCOTT WW. MERCUROCHROME-220 SOLUBLE AS A BILIARY ANTISEPTIC: AN EXPERIMENTAL STUDY. Arch Intern Med (Chic). 1925;35(4):503–515. doi:10.1001/archinte.1925.00120100101009
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