The method of measuring total blood volume by determining the degree of dilution of the transfused corpuscles among the corpuscles of the recipient, previously described,1 has been applied to cases of secondary anemia, primary anemia, and hemorrhage resulting from operation; the results obtained are compared with the data already on record derived by the use of vital red in similar groups of cases. Since, as has been shown, this method is based on a determination of corpuscle content, a comparison of the results obtained by it with those obtained by a method in which the whole blood volume is calculated from a determined plasma volume is of interest because of its bearing on the problem of the uniformity of distribution of the red corpuscles in the circulation.
The means of measuring plasma volume are numerous. The most satisfactory is the injection of a substance, soluble in the plasma, and the
ASHBY W. BLOOD VOLUME: II. A COMPARISON BETWEEN TOTAL BLOOD VOLUMES DETERMINED BY PLASMA VOLUME METHODS AND BY A NEW CORPUSCLE VOLUME METHOD. Arch Intern Med (Chic). 1925;35(5):632–640. doi:10.1001/archinte.1925.00120110098012
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