Diurnal fluctuations in the count of corpuscles derived from a transfusion appear to have a consistent trend in patients with anemia, and are assumed to indicate blood volume changes. Changes incident to transfusion, pointing to a reduced blood volume following a transfusion reaction, have also been noted.
Little attention has been given to rapid fluctuations in the blood count, and the possibility of their occurrence is often lost sight of. Limbeck1 studied the changes in the red and white cell count after eating, and reports a drop in the red cell count. He found a count of 5,550,000 before the meal, 5,320,000 a quarter of an hour after the meal, 5,480,000 an hour and a quarter after, 4,730,000 two hours and a quarter after, 4,870,000 three and a quarter hours after, and 4,720,000 four hours and a quarter after. In reviewing the literature, he found that Sorenson noted an increase
ASHBY W. BLOOD VOLUMEIV. DIURNAL FLUCTUATIONS IN BLOOD VOLUME AND CHANGE INCIDENT TO TRANSFUSION REACTION. Arch Intern Med (Chic). 1925;35(6):726–732. doi:10.1001/archinte.1925.00120120057004
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