The blood volume of patients with pernicious anemia was calculated from the count of unagglutinable corpuscles during the course of a series of transfusions. The number of corpuscles for each cubic millimeter was counted, the total number of corpuscles present in the circulation computed, and an attempt was made to correlate the three factors, blood volume, red cell count and total number of corpuscles, with the general condition of the patient.
The studies were started simultaneously with the treatment of a patient who either had not been treated before, or who had come back for a course of treatment after a relapse. A transfusion of unagglutinable corpuscles was given first, followed by a series of transfusions of blood of the same group as that of the patient. These studies were made incidental to a study of the rate of elimination of transfused blood in patients with pernicious anemia. At the
ASHBY W. BLOOD VOLUME: V. THE EFFECT OF TREATMENT ON THE BLOOD VOLUME OF PATIENTS WITH PERNICIOUS ANEMIA. Arch Intern Med (Chic). 1925;35(6):733–739. doi:https://doi.org/10.1001/archinte.1925.00120120064005
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