The work reported here was done in 1919. In view of the then prevailing association of a much reduced blood volume with pernicious anemia and the reported decrease in alkalinity of the serum, it seemed within the bounds of probability that if the total carbon dioxid elimination had to be taken care of by a reduced amount of blood, the level of the carbon dioxid in each unit of blood would be raised, and that the increase in hydrogen concentration resulting might in turn tend to maintain a reduced blood volume.
I therefore attempted to see to what such an hypothesis would lead by a study of the effect on blood volume of a decrease in the hydrogen ion concentration of the blood brought about by administration of carbonates to two patients with pernicious anemia who had received transfusions of unlike group blood. Changes in the concentration of the unagglutinable
ASHBY W. BLOOD VOLUME: VI. THE RELATIONSHIP BETWEEN BLOOD VOLUME, TOTAL CORPUSCLE CONTENT AND ALKALINE RESERVE IN CASES OF PERNICIOUS ANEMIA. Arch Intern Med (Chic). 1925;36(1):24–30. doi:10.1001/archinte.1925.00120130027003
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