In 1906 B. Fischer introduced drops of a saturated solution of scharlach r in olive oil directly under the epidermis of the ears of rabbits. He notes that the epithelial cells grew down to surround these oil droplets. The histologic picture of this growth of the epithelial cells resembled epitheloid cancer in many cases, but these formations always ceased to proliferate and regressed after a time. Reinke introduced drops of ether into the eye of salamanders. A growth of cells was induced by the presence of this substance. He transplanted this new growth to the peritoneal cavity and found it continuing to proliferate for a time. White succeeded in inducing epithelial activity with drops of oleic acid, and Strober and Wacker with sudan III, indol and skatol. Benthin used several such materials, and Bullock and Rohdenberg and others have tried the effect of introducing scharlach r into various internal organs.
BURROWS MT, JOHNSTON CG. THE ACTION OF OILS IN THE PRODUCTION OF TUMORSWITH A DEFINITION OF THE CAUSE OF CANCER. Arch Intern Med (Chic). 1925;36(3):293–332. doi:10.1001/archinte.1925.00120150002001
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