It has been known for a long time that the administration of urea in large doses produces a considerable increase in the volume of urine. Urea was, however, until comparatively recently little utilized for its diuretic properties. This was doubtless due to the prevailing idea that urea retention was the causative factor in uremia. Urea was considered a harmful substance and any measures undertaken to raise its concentration in the body were regarded with disfavor. With the advance of clinical chemistry it soon came to be recognized that although the urea in the blood is raised in uremia it is not the cause of the condition. It became established that if the function of the kidney is good urea can be given to patients for prolonged periods of time with impunity. Even in cases in which kidney disease was known to be present, large doses of urea have been given
CRAWFORD H, McINTOSH JF. THE USE OF UREA AS A DIURETIC IN ADVANCED HEART FAILURE. Arch Intern Med (Chic). 1925;36(4):530–541. doi:10.1001/archinte.1925.00120160088004
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