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November 1925


Author Affiliations


From the Department of Internal Medicine, University of Michigan Medical School.

Arch Intern Med (Chic). 1925;36(5):682-711. doi:10.1001/archinte.1925.00120170091007

It has been shown by Newburgh and his collaborators1 (1919, 1923) that high protein diets produce renal injury in rabbits, and by Polvogt, McCollum and Simmonds2 (1923) that similar diets have a harmful effect on the kidneys of rats. In explanation of this fact, a number of possibilities present themselves for consideration, among which are: (1) poisonous products arising from the action of bacteria on the food in the intestine; (2) the absorption of foreign protein forced into the blood by the excess in the intestine; (3) the excretion of an acid urine from diets high in certain proteins; (4) extra work required of the kidney by the increased nitrogen metabolism, and (5) lack of vitamins. No evidence in favor of any of these explanations was obtained.

In a previous article, it was suggested that the amino-acids themselves might be the source of the renal injury. That both the absorption