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November 1925


Arch Intern Med (Chic). 1925;36(5):724-734. doi:10.1001/archinte.1925.00120170133009

In the course of studies on the lymphatic system of the eye I made use of a drug that is known to produce edema of the orbital tissue and bulging of the eyeball. This drug is paraphenylendiamin hydrochlorid, which is used in dyeing furs and feathers and which also is the chief constituent of certain hair dyes. According to Birch-Hirschfeld,1 the edema produced by this substance is essentially stasis of lymph, the result of which is dilatation of the lymph vessels, and he states that he has been able by this means to demonstrate a lymphatic apparatus in the orbital tissue. My observations of the action of paraphenylendiamin on the lymphatic system have been discussed in a previous paper.2 Because of the peculiar symptom complex that follows the injection of paraphenylendiamin and because of very marked differences in the effect of the drug in different species of animals, I carried

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