Nonspecific desensitization and nonspecific protein therapy have become recognized factors in immunity. Rosenau and Anderson1 have shown that animals receiving repeated injections of foreign proteins become markedly insusceptible to anaphylactic shock. Longcope2 writes: "It seems impossible to avoid the conclusion that in animals sensitized to two proteins anaphylactic shock to the one reduces temporarily the sensitiveness to the second." Dale3 found that a guinea-pig sensitized to several serums and also to egg white could be desensitized to the serum with egg white. Kolmer,4 in referring to nonspecific protein therapy, says that "nonspecific activities of bacterial vaccine may exert beneficial and curative effects in disease to which the bacteria incorporated in the vaccine has no etiologic relationship."
CLINICAL REPORTS ON NONSPECIFIC DESENSITIZATION IN ASTHMA
Numerous clinical reports are accumulating which show the beneficial effect of various nonspecific desensitizing agents in asthma as well as in hay-fever, and other sensitization conditions. Miller5
SPANGLER RH. NONSPECIFIC DESENSITIZATION THERAPY IN ALLERGIC ASTHMA: THE EOSINOPHILIC INDEX AS A GUIDE TO INTRAMUSCULAR INJECTION OF VENOM PROTEIN, WITH CASE REPORT. Arch Intern Med (Chic). 1925;36(6):779–787. doi:10.1001/archinte.1925.00120180031004
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