The discovery and isolation of the physiologically effective principle of the internal secretion of the pancreas by Banting and Best1 in 1921 may be considered the culmination of the great amount of research work which received its impetus from the fundamental facts established by von Mehring and Minkowski in 1889.2 At that time it was first found that pancreatectomy in dogs resulted in complete diabetes. Thirtytwo years of research on carbohydrate metabolism and the problem of diabetes mellitus prepared the way for the important findings of Banting and Best which resulted in the isolation of insulin and its application as a therapeutic agent. The work of von Mehring and Minkowski was the first contribution of value toward a solution of the question of the etiology of diabetes mellitus. Through the work of Banting and Best it is now known that the pancreas secretes a hormone which is essential to normal
MUELLER EF, WIENER HJ, WIENER RV. THE MECHANISM OF INSULIN ACTION. Arch Intern Med (Chic). 1926;37(4):512–540. doi:10.1001/archinte.1926.00120220062004
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