The production of high fevers in animals by dehydration has been the subject of much discussion and the literature is full of reports of exceedingly contradictory results. While our knowledge of the behavior of dehydrated infants (inanition fevers), reinforced by reports of exceedingly high temperatures produced by this means in animals, leaves no doubt that the loss of the water reserve of the body is an exceedingly important factor in temperature control, these fevers have followed no regular rule. Their artificial production is uncertain and inexplicable on the basis of dehydration alone, and so many discrepancies have occurred that many observers have denied the existance of such fevers altogether, attributing the fevers that do occur to some uncontrolled factors in these experiments. The three most commonly mentioned factors are: (1) impurities in the glucose used for dehydrating the animal (dextrins, acid elements, etc.); (2) free hydrochloric acid in the physiologic
ANDREWS E. WATER METABOLISM: III. DEHYDRATION FEVERS. Arch Intern Med (Chic). 1926;37(6):815–818. doi:10.1001/archinte.1926.00120240087007
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