Several tests have been recently advocated for the determination of "activity" in tuberculosis. The more prominently mentioned are the Frisch and Starlinger,1 Gerlóczy,2 Mátéfy,3 Darányi,4 and erythrocyte sedimentation5 reactions. These tests are not specific for tuberculosis and are obtainable in all conditions in which there is an accompanying tissue destruction, their utility being comparable to that of a clinical thermometer. We have had occasion to observe the sedimentation reaction on several hundred tuberculous patients and have been impressed with its usefulness in gaging the toxicity of a tuberculous process. When used in conjunction with other clinical and laboratory means of investigation, the test offers a valuable addition to the study of a patient's progress. The results that have been reported from the use of the other named tests, although not as favorable as those that have been obtained with the sedimentation reaction, nevertheless seem to indicate that the physicochemical structure
RUBIN EH. THE RELATION OF THE ERYTHROCYTE SEDIMENTATION REACTION TO THE ABILITY OF FLOCCULATION OF THE PLASMA AND SERUM. Arch Intern Med (Chic). 1926;37(6):848–860. doi:10.1001/archinte.1926.00120240120009
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