The organism of syphilis invades the blood stream early in the infection, and it is generally admitted that during this period of invasion the treponemes lodge in the various viscera, including the heart and the aorta. Then follows a considerable latent period, after which symptoms and signs of syphilitic heart and aortic disease may become manifest, usually a number of years after the original infection.Recently, however, there have been several reports emphasizing that signs of involvement of the heart and aorta in syphilis appear in the early stages of the disease. This is logical in view of the known facts pertaining to syphilitic infection, but is not well borne out in the clinical experience of many observers. Because we have felt that many of the reported cases have not been critically enough examined, we undertook the investigation described in this report.
Grassman's1 work is quoted in most
TURNER KB, WHITE PD. THE HEART AND THE AORTA IN EARLY SYPHILIS: CLINICAL OBSERVATIONS. Arch Intern Med (Chic). 1927;39(1):1–11. doi:10.1001/archinte.1927.00130010006001
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