Clinical studies of human lead poisoning, particularly those of a statistical nature, have from time to time resulted in the conclusion that some degree of tolerance to the manifestations of this condition may be acquired through prolonged exposure to lead. The possibility of such an acquisition and the fact of its occurrence have been just as vigorously denied from other sources. It is the purpose of this article to show by an experimental method that, with the animal species used and methods employed, there can be demonstrated a marked degree of tolerance to the meningocerebral manifestations of lead poisoning. Thus, in still another instance has a clinical belief developed through careful case observation and statistical analysis found verification, although somewhat tardily, through laboratory investigation. Tanquerel des Planches1 in discussing a tabular survey of cases of lead encephalopathy said, "This table proves, among other things, that the greater number of patients
WELLER CV. TOLERANCE IN RESPECT TO THE MENINGOCEREBRAL MANIFESTATIONS OF ACUTE AND SUBACUTE LEAD POISONING: EXPERIMENTAL PRODUCTION. Arch Intern Med (Chic). 1927;39(1):45–59. doi:10.1001/archinte.1927.00130010050004
Browse and subscribe to JAMA Network podcasts!
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: