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Article
January 1927

THE MECHANISM OF PAIN IN GASTRIC AND IN DUODENAL ULCER: III. THE RôLE OF PERISTALSIS AND SPASM

Arch Intern Med (Chic). 1927;39(1):109-133. doi:10.1001/archinte.1927.00130010114009
Abstract

It has been shown that hydrochloric acid is an irritant that constitutes an adequate stimulus to the pain-producing mechanism of a sensitive ulcer. In this article data are reported regarding, first, the rôle of peristalsis and spasm in the distress so produced, and, second, the effect of peritalsis as a mechanical stimulus to the pain-producing mechanism. This evidence gives some information as to the relationship of the pain-producing mechanism to the ulcer.

LITERATURE  In 1916, Ginsberg, Tumpowsky and Hamburger1 reported the first experiments showing a muscle tension factor in ulcer pain. The following year Carlson2 published some excellent kymographic tracings showing intermittent ulcer pain synchronous with gastric contractions, and concluded also that the pain was due, not to the acidity per se, but to the muscle tension. Hardt,3 on the basis of similar work, drew the same conclusion a year later. In 1919 Homans4 took exception to this view and

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