As a part of a large group of studies which have been in progress for a number of years at the Mayo Clinic, it has been necessary to learn whether the yellow pigment in the blood serum of patients suffering from pernicious anemia, hemolytic jaundice, obstructive jaundice and severe toxic diseases, such as malaria, was the same substance and whether this pigment was present in smaller amounts in normal blood serum. The answer to this question obviously has much to do with the understanding of the formation of bile and the destruction of erythrocytes.
We have shown that following total removal of the liver,1 a yellow pigment rapidly accumulates which is found in the blood serum, fat and urine of the animal. Intensive investigation of this phenomenon has led to the conclusion that the substance is bilirubin and is exactly like that found in the serum of animals in which
MAGATH TB, SHEARD C. SPECTROPHOTOMETRIC ANALYSIS OF BLOOD SERUM IN NORMAL AND PATHOLOGIC CONDITIONS: STUDY I. Arch Intern Med (Chic). 1927;39(2):214–225. doi:10.1001/archinte.1927.00130020053004
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