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Article
March 1927

BILIARY, PANCREATIC AND DUODENAL STUDIESII. ESTIMATION OF PANCREATIC ENZYMES AND VALUE OF SUCH DETERMINATIONS FROM A CLINICAL STANDPOINT

Arch Intern Med (Chic). 1927;39(3):343-355. doi:10.1001/archinte.1927.00130030028003
Abstract

The functions of the pancreas will never be understood until there are methods for ascertaining its fundamental physiology. On this question a great deal of work is now being done. Of course, the function of the pancreas that is most obvious is the enzyme secretion. How to estimate it in some manner accurate enough for clinical investigation is the problem discussed in this article. There has been a great deal of study of the pure secretion, but that is of only academic help in the clinical problems.

A method of approach which will give a fairly faithful record of the functional state of the pancreas in its production of the so-called external enzymes is offered here. To begin with, an estimation was made of the amount of starch digested as shown in various dilutions of duodenal contents with the aid of iodine. Among the first to do this was Dr.

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