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March 1927


Author Affiliations


From the Department of Medicine, University of Wisconsin.

Arch Intern Med (Chic). 1927;39(3):385-403. doi:10.1001/archinte.1927.00130030070006

Since the isolation of pure ephedrine by Nagai in 1887,1 several clinical observations have been made with regard to its mydriatic action. Thus Miura2 in the same year reported that a 6 to 7 per cent solution of ephedrine hydrochloride produces mydriasis in most people in from forty to sixty minutes. He observed that the use of a 10 per cent solution in eighteen patients did not cause a maximal dilatation of the pupils but produced sufficient dilatation for the visualization of the retina. During dilatation, the light reflex is retained, and the accommodation is not paralyzed. There is no increase in intra-ocular pressure, no irritation or inflammation after its instillation and no ill effects after prolonged use. One patient receiving three treatments daily for fifteen days showed no pathologic changes. The duration of mydriasis varies from five to twenty hours. Children and aged people are more susceptible than young

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