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March 1927


Author Affiliations


From the medical service of the Collis P. Huntington Memorial Hospital of Harvard University.

Arch Intern Med (Chic). 1927;39(3):412-420. doi:10.1001/archinte.1927.00130030097008

The study of the destruction of glucose by the cells of the body has recently received a new impetus through the discovery by Warburg1 that tumor tissues have quantitative and qualitative differences from the normal, with regard to their carbohydrate metabolism. Warburg found that the glycolytic activity of malignant tumor tissues in human beings and in rats was many times greater than that of normal tissues when studied under aerobic or anaerobic conditions in a respiration apparatus.

Warburg's work has been largely confirmed by Murphy and Hawkins.2 They have noted certain exceptions to his general conclusions and point out that glycolytic activity bears no close relationship to rate of growth. Nevertheless, they conclude that Warburg's studies have opened a new and fruitful field for research in cancer.

It seemed possible to acquire further data on the problem by the investigation of glycolysis in certain disorders of the blood—especially in the