In an attempted analysis of the complicated conditions found in organic heart "disease in man, studies of experimental lesions in the laboratory animal are of recognized value. The great value of the experimental procedure is the production, at least initially, of a single restricted lesion, a knowledge of the date of its incidence and the possibility of subsequent unrestricted observation. Although a large amount of work has been done in studies of both the clinical condition occurring in man and the functional and anatomic sequences of experimental lesions, we are far from a satisfactory understanding or agreement in regard to certain of the most fundamental questions. Two of the more important of these considerations are the cause and progress of the hypertrophy of the cardiac muscle which accompanies most cases of organic heart disease and the alterations frequently observed in the electrocardiogram in clinical cases. The series of experiments described
EYSTER JAE, MEEK WJ, HODGES FJ. CARDIAC CHANGES SUBSEQUENT TO EXPERIMENTAL AORTIC LESIONS. Arch Intern Med (Chic). 1927;39(4):536–549. doi:10.1001/archinte.1927.00130040074007
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