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Article
May 1927

RELATION BETWEEN CELL COUNT, CELL VOLUME AND HEMOGLOBIN CONTENT OF VENOUS BLOOD OF NORMAL YOUNG WOMEN: REDETERMINATIONS OF COLOR INDEX, VOLUME INDEX AND SATURATION INDEX STANDARDS BASED ON OBSERVATIONS IN ONE HUNDRED CASES

Author Affiliations

PORTLAND, ORE.

From the Department of Biochemistry, University of Oregon Medical School.

Arch Intern Med (Chic). 1927;39(5):643-655. doi:10.1001/archinte.1927.00130050040005
Abstract

The need for a definite accepted figure, expressed in grams per one hundred cubic centimeters, as the standard of average hemoglobin content of normal blood has been emphasized recenty.1 Few physicians, however, realize that the figures usually given in the texts for average normal red cell counts (5 million for men and 4.5 million for women) are apparently based on only four blood examinations made in 18522 and 18543 by methods which are now obsolete. These figures have since been copied from one textbook to another without experimental confirmation. The increasing use of volume index, saturation index and color index determinations in the differential diagnosis of anemia demands that the normal averages and ranges of variation in these observations be determined accurately.

In this article we present the results of accurate red cell counts, hemoglobin determinations and cell volume determinations on 100 healthy young women, and give the average and

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