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July 1927


Author Affiliations


From the Laboratories of the Mount Sinai Hospital.

Arch Intern Med (Chic). 1927;40(1):80-97. doi:10.1001/archinte.1927.00130070083008

It has been known since the time of Gull and Sutton1 that lesions of the arterioles are present in many cases of arterial hypertension. In a previous communication2 I presented the results of a study of the arteriolar lesions of essential hypertension. Under this term were included the numerous—and probably etiologically diverse— "cases of chronic hypertension which neither clinically nor anatomically can be demonstrated to have evolved from antecedent inflammatory disease of the kidneys or from urinary obstruction." It was concluded that the arteriolar lesions (arteriolosclerosis) occurring in essential hypertension result from the increased wear and tear incidental to the hypertension, being a pathologic exaggeration of similar, though slighter, changes in the arterioles which are a physiologic accompaniment of advancing years.

If the view that the arteriolosclerotic lesions are the result of the hypertension is correct, it would be expected that these lesions would be found not only in essential