Multiple myeloma is a disease of the bone marrow characterized by the appearance of multiple focal lesions which exhibit certain neoplastic properties. The histologic picture is that of a proliferation of apparently some one cell of the marrow, but the histogenetic identity is still unsolved. Metastases have been reported but are rare. Bence-Jones protein in the urine is a frequent accompaniment. All cases reported have terminated fatally, usually after having run a slow, progressive course.
The first case of this disease reported was that of McIntre, in 1850, under the term mollities ossium. In 1867, Wever reported another case. Von Rustisky in 1873, first recognized the involvement of the bone marrow and gave it the name it now bears, multiple myeloma. In 1905, Wood was able to collect only thirty instances of this disease;1 fifty had been collected in 1912, and a hundred by 1920. Since then the total has
CHARLTON TJ. MULTIPLE MYELOMA: WITH REPORT OF A CASE. Arch Intern Med (Chic). 1927;40(1):98–109. doi:10.1001/archinte.1927.00130070101009
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