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Article
October 1927

DISEASES OF THE LIVER: VII. FURTHER STUDIES IN EXPERIMENTAL OBSTRUCTIVE JAUNDICE

Author Affiliations

ROCHESTER, MINN.

From the Division of Medicine, Mayo Clinic and The Mayo Foundation.

Arch Intern Med (Chic). 1927;40(4):471-487. doi:10.1001/archinte.1927.00130100075005
Abstract

In a previous paper we have reported the effect of experimental obstructive jaundice on hepatic function as measured by certain tests.1 At that time particular attention was paid to the changes in the fructose tolerance, the nitrogen partition in the blood, the serum bilirubin and the phenoltetrachlorphthalein test.2 We now wish to report further studies with particular reference to the bromsulphalein test of Rosenthal and White,3 the bile acid content of the blood and the elimination of intravenously injected bile acids. The serum bilirubin was followed as an index to the degree of jaundice, a standard of reference being thus furnished for the comparison of the results in the two series of experiments.

Two groups comprising a total of fifteen animals were studied: those in which the common duct had been ligated, and those in which cholecystectomy had been performed in addition to ligation of the common duct. In all

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