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Article
October 1927

EXPERIMENTAL UREMIA

Arch Intern Med (Chic). 1927;40(4):548-570. doi:10.1001/archinte.1927.00130100152011
Abstract

In previous papers,1 it was shown that diuresis would not occur in animals suffering from acidosis as evidenced by a low alkali reserve (Van Slyke) even under the extreme provocation of the injection of 25 cc. of a 5 per cent solution of sodium chloride per kilogram of body weight. The following experiment is illustrative of what happens in more extreme acidosis.

EXPERIMENTS ON DOGS  Sodium chloride in the dosage mentioned was injected for ninety minutes into a dog weighing 17 kilograms. In this experiment the flow of urine lagged far behind the rate of injection, so that when the animal died after two and one-fourth hours, his water balance was 595 cc. plus. This failure of diuresis will result from acidosis of various kinds. The types that I have noted as demonstrated in experimental work include: (1) starvation acidosis, (2) exhaustion acidosis, (3) acidosis caused by acute respiratory infections,

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