In January, 1921, we instituted a study of fifty unselected cases of fully developed exophthalmic goiter.1 No specific therapeutic measures were employed in order to determine the natural history (spontaneous course) of the disease,2 and to establish an index for the evaluation of therapeutic procedures.3 From the group were excluded (a) patients who had thyroid enlargement without other manifestations of exophthalmic goiter4 and (b) those who, with or without thyroid enlargement, presented sympathomimetic symptoms, without significant elevation of the basal metabolism (autonomic imbalance).5 In the group studied, we included (1) patients with a significant elevation of metabolism on repeated readings; (2) patients whose illness was sufficiently severe to warrant residence in a hospital in which beds are at a great premium; and (3) patients from the poorest sections of the city, who were subjected to constant economic strain.
The present study is for the purpose of evaluating the efficacy of
KESSEL L, HYMAN HT. EXOPHTHALMIC GOITER AND THE INVOLUNTARY NERVOUS SYSTEM: XVI. THE INFLUENCE OF SUBTOTAL THYROIDECTOMY WITH AND WITHOUT COMPOUND SOLUTION OF IODINE ON THE COURSE OF THE DISEASE. Arch Intern Med (Chic). 1927;40(5):623–636. doi:10.1001/archinte.1927.00130110051005
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