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Article
November 1927

WATER METABOLISM: V. EFFECT OF VARYING DEGREES OF HYDRATION ON SUGAR METABOLISM

Author Affiliations

CHICAGO

From the Department of Surgery, University of Illinois College of Medicine.

Arch Intern Med (Chic). 1927;40(5):637-646. doi:10.1001/archinte.1927.00130110065006
Abstract

In a previous communication,1 it was shown that the relative hydration of the organism had a profound effect on the sugar metabolism. If one-half unit of insulin per kilogram of body weight was injected into dogs in varying degrees of dehydration, the hypoglycemic effect was not only intensified, but it was also materially prolonged. This paper consists of further studies on the subject.

The experiments were repeated on diabetic dogs. We used not only dogs with complete diabetes, but also a dog in which the diabetes was not complete, so that he was able to remain in fairly good health for several months without the use of insulin, except as it was required for the experiments. The blood sugar estimations were made by the micro method of Folin-Wu.2

Chart 1 is a control showing the normal curve of a diabetic animal. The noontide hypoglycemia which has already been studied and

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