[Skip to Navigation]
November 1927


Author Affiliations

George W. Crile Fellow in Research Medicine CLEVELAND

From the Department of Medicine of Lakeside Hospital and Western Reserve University.

Arch Intern Med (Chic). 1927;40(5):661-667. doi:10.1001/archinte.1927.00130110091008

A larger proportion of the recorded insulin reactions has occurred at a time when the analyses of the blood sugar have shown normal or elevated blood sugar concentrations. Many severe reactions have been observed at times when the blood sugar concentrations have been from 250 to 350 mg. per hundred cubic centimeters of blood or even higher. These experiences have caused many observers to suspect that the fundamental cause of the so-called "hypoglycemic reaction" is not the hypoglycemia. Various explanations have been offered in an attempt to reconcile the severe reaction with a high blood sugar content. So far as I know, none of these has been free from serious criticism, and none has been a real explanation for every observed reaction, with the exception of the one offered here. This idea was first published two years ago.1 Since that time, more evidence has been accumulated which seems to confirm

Add or change institution