In recent years, interest in jaundice has been largely transferred from the color of the skin and the presence or absence of bile pigment in the urine and feces to the changes occurring in the blood serum, much in the same way that physicians have become concerned with the urea content of the blood in nephritis, and with the concentration of blood sugar in cases of diabetes mellitus. The introduction of new and more delicate methods for the detection and estimation of bilirubin in the serum is responsible for this change in point of view. Perhaps the most notable method has been that of Hijmans van den Bergh of Utrecht, Holland,1 popularized among the English speaking peoples by the publications of McNee of the University College of London.2
Estimations of serum bilirubin are necessary for the detection of potential or latent and also of transient states of jaundice, for the
SCHIFF L. SERUM BILIRUBIN IN HEALTH AND IN DISEASE. Arch Intern Med (Chic). 1927;40(6):800–817. doi:10.1001/archinte.1927.00130120059004
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