[Skip to Content]
[Skip to Content Landing]
Article
December 1927

EXPERIMENTAL OBSTRUCTIVE JAUNDICEI. GROWTH FACTOR IN DEFECTIVE CALCIFICATION

Arch Intern Med (Chic). 1927;40(6):900-910. doi:10.1001/archinte.1927.00130120159011
Abstract

It is our purpose to present in this paper the roentgenographic evidence of a high grade osteoporotic condition developing in the long bones of jaundiced puppies and to give further data on the blood calcium of these animals. The results obtained from a study of several litters enable us to present a more comprehensive report and to substantiate the observation made recently1 that a fairly uniformly progressive calcium deficiency occurs during this early period of growth. Whereas progressive loss in weight and cachexia obtain for the jaundiced adult animal, the young one shows a progressive gain in weight which is appreciable at the time of death, although emaciation may have supervened. Investigators in this field have limited themselves entirely to a study of the adult animal, and extended work has not been carried out on the very young. It seemed advisable, therefore, to investigate further the disturbances which might be

×