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Article
December 1927

EXPERIMENTAL OBSTRUCTIVE JAUNDICE: I. GROWTH FACTOR IN DEFECTIVE CALCIFICATION

Author Affiliations

CHICAGO

From the Nelson Morris Fund and the John D. and Fannie K. Hertz Fund of the Michael Reese Hospital, the Nelson Morris Institute for Medical Research, and the Department of Physiology of the University of Chicago.

Arch Intern Med (Chic). 1927;40(6):900-910. doi:10.1001/archinte.1927.00130120159011
Abstract

It is our purpose to present in this paper the roentgenographic evidence of a high grade osteoporotic condition developing in the long bones of jaundiced puppies and to give further data on the blood calcium of these animals. The results obtained from a study of several litters enable us to present a more comprehensive report and to substantiate the observation made recently1 that a fairly uniformly progressive calcium deficiency occurs during this early period of growth. Whereas progressive loss in weight and cachexia obtain for the jaundiced adult animal, the young one shows a progressive gain in weight which is appreciable at the time of death, although emaciation may have supervened. Investigators in this field have limited themselves entirely to a study of the adult animal, and extended work has not been carried out on the very young. It seemed advisable, therefore, to investigate further the disturbances which might be

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