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January 1928


Arch Intern Med (Chic). 1928;41(1):66-74. doi:10.1001/archinte.1928.00130130069007

In recent years there has developed a general belief that so-called adenomatous goiter with hyperthroidism (toxic adenoma) and exophthalmic goiter are two separate diseases. Still more recently, this belief has been emphasized by the common acceptance of the view that iodine, though beneficial under certain conditions in exophthalmic goiter, is harmful to and contraindicated in cases of toxic adenoma. Such a difference in response to iodine might well be expected to occur were it true that a fundamental difference exists between these two types of thyrotoxicosis. However, conclusive evidence of such a difference has not been presented, and it seemed that further evidence concerning the nature of toxic adenoma would be obtained by a trial of the effect of iodine in such cases. Such a study could be expected to furnish further evidence of the relation existing between exophthalmic goiter and toxic adenoma. In 1924, we therefore began a study