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March 1928


Arch Intern Med (Chic). 1928;41(3):343-345. doi:10.1001/archinte.1928.00130150050003

Agranulocytic angina was first reported by Schultz1 in 1922. In June, 1927, Kastlin2 reported two cases and reviewed forty-one previously reported. Since Kastlin's monograph, Linthicum3 has reported two cases and Finnegan4 one. Of the forty-seven cases reported (including the one given below), forty-three (91 per cent) terminated fatally. Thirty-seven (78 per cent) occurred in females, the majority of whom were past the age of 40. In only one case was there a history of a previous attack.

The disease is characterized by an acute onset with a temperature of from 101 F to 105 F., with great prostration, sore throat or mouth and severe headache. It is sometimes accompanied by chills, general muscle pains, vomiting, herpes, bleeding from the oral and vaginal mucosa and jaundice. A membrane is usually present either in the region of the tonsils or along the gingival margins. In the fatal jases, the external genitalia are