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Article
March 1928

EXPERIMENTAL ANEMIA PRODUCED BY CLOSTRIDIUM WELCHII: CHEMICAL ANALYSIS OF THE BLOOD

Author Affiliations

NEW YORK

From the Department of the Laboratories, New York Post-Graduate Medical School and Hospital.

Arch Intern Med (Chic). 1928;41(3):370-384. doi:10.1001/archinte.1928.00130150077005
Abstract

In a preceding paper,1 the general problem of the significance of the anaerobic intestinal bacteria in relation to human disease was presented, and experimental studies of these microbes, more especially of those belonging to the species Clostridium welchii, were described. A toxic anemia of severe grade was induced by inoculation of these organisms.

A comparison of the results of chemical analyses of the blood of these experimental animals with similar results on control normal animals, and especially with analogous results obtained in clinical diseases of man, is our purpose in the present communication. The difficulty of applying conceptions derived from animal experimentation at once in clinical medicine is keenly appreciated. Nevertheless, living things have much in common, and the results of animal experimentation have already proved of value in the study of anemia.

In the present study, attention has been devoted especially to that group of experimental animals in which

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