The basis of this paper is a study of the occurrence of allergic manifestations in the E. Family, including the direct descendants of W. G. E. (1) and A. A. E. (2). The study includes observations on eighty-seven persons and five generations. Certain introductory statements should be made. The genealogical chart shows that W. G. E. (1) was the son of first cousins and that he married the first cousin of both his parents; hence, a considerable reinforcement of inherited characters must have occurred in the f-1 generation. W. G. E. (1), his wife, A. A. E. (2), and his sister, C. E. L. (0), were all hypersensitive. Information cannot be obtained concerning allergic manifestations in their parents. A. A. E. (2) and W. G. E. (1) had fourteen children, of whom nine died in early life. It has not been possible to obtain histories of these nine children other
SMITH AE. OCCURRENCE OF HYPERSENSITIVENESS OR ALLERGY IN FIVE GENERATIONS OF ONE FAMILY. Arch Intern Med (Chic). 1928;41(4):472–481. doi:10.1001/archinte.1928.00130160022002
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