Notwithstanding the fact that increased destruction of blood in pernicious anemia was demonstrated over thirty years ago by Hunter,1 it would appear from a careful search of the literature that a direct destructive action of the blood serum on the red corpuscles in this disease has not been demonstrated. The bulk of the research on the mechanism of erythrocyte destruction in pernicious anemia appears to have been directed toward the demonstration of a localization of the process in certain organs, especially in the bone marrow, spleen, hemolymph nodes and liver. The investigations have been carried out principally along three different lines of pursuit: (1) histologic studies of the phagocytic activity of the cells of the different organs, (2) the quantitative determination of the iron content of these organs, and (3) the isolation of hemolytic substances from these organs.
Hunter found excessive deposits of pigment in the cells of the livers
HORRALL OH, BUCHMAN TE. HEMOCIDAL PROPERTIES OF THE BLOOD SERUM: WITH SPECIAL REFERENCE TO PERNICIOUS ANEMIA. Arch Intern Med (Chic). 1928;41(4):482–498. doi:10.1001/archinte.1928.00130160032003
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