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The purpose of this paper is to compare the relative value in diagnosis of certain of the more classic symptoms and signs of hyperthyroidism. The criteria used are: (a) the bedside data furnished by these symptoms and signs themselves as compared with (b) the basal metabolic rate and (c) the pathologic examination of the resected thyroid gland when this material is available.
The method consists of arbitrarily assigning the values shown to the following six symptoms and signs: nervousness, 1; tremor, 2; loss of weight, 3; tachycardia, 4; exophthalmos, 5 and goiter, 6, making a total of 21. By this means a numerical index of symptoms is arrived at which can be readily represented graphically on a chart showing the relation of the numerical index to the basal metabolic rate.
Nervousness is a subjective symptom, vague in its definition, characteristic of a wide variety of diseases and not quantitively measurable.
SMITH JH. BASAL METABOLISM: II. THE BASAL METABOLIC RATE IN RELATION TO SYMPTOMS AND SIGNS IN HYPERTHYROIDISM. Arch Intern Med (Chic). 1928;41(6):830–833. doi:10.1001/archinte.1928.00130180063003
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