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Article
July 1928

THYROID DISEASE: AN EXPERIMENTAL STUDY

Author Affiliations

DETROIT

From the Buhl Laboratory and the Surgical Service of the Harper Hospital.

Arch Intern Med (Chic). 1928;42(1):1-13. doi:10.1001/archinte.1928.00130190004001
Abstract

The pathogenesis, classification and treatment of the diseases of the thyroid gland continue to be subjects of considerable controversy. Although the etiologic relationship of the thyroid gland to exophthalmic goiter was at one time considered definitely proved, a small group of dissenters have maintained that the thyroid gland cannot be considered more than a single link in the chain of a complicated disease.

Hoover,1 for example, said:

Men write very freely about the excessive flow of internal secretions from a hyperplastic thyroid into the circulation, but this is certainly not true of myxedema and it has never been proved to be true in Grave's disease. In fact, no one has thus far offered anything but inferential or fancied evidence for hyperthyroidism, and that has been so feeble that it will not stand critical inspection.

Israel Bram2 went even further, and said:

The question involved is not that of a "lump

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