Various procedures have been recommended for measuring gastric secretion in man. Certain English investigators1 have suggested that the total chlorides of a sample of contents of the stomach as determined by the direct Volhard method, after filtration but without ashing, is more accurate than the acidity as an index to the amount of gastric secretion, because much or little of the acid secreted may have been neutralized. They state further that a comparison of the acidity, as determined by the Toepfer method, and the total chlorides gives information as to the amount of neutralization that has occurred. However, this depends on the hypothesis that the chief source of the chlorides in the stomach is hydrochloric acid, an assumption of fundamental importance and one worthy of investigation.
In this paper, we report the results of a comparative study of the total chloride concentration and acidity of the gastric contents in a
GORHAM FD, STROUD CM, HUFFMAN M. TOTAL CHLORIDE CONCENTRATION AND ACIDITY OF THE GASTRIC CONTENTS: A COMPARATIVE STUDY. Arch Intern Med (Chic). 1928;42(1):106–116. doi:10.1001/archinte.1928.00130190109010
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