Since the description by Addison, in 1855, of the disease that bears his name, many articles have been written on dysfunction of the suprarenal glands, and many cases have been reported that have shown the picture of insufficiency of these glands as described by him. Most of the autopsies reported have shown destruction of the suprarenal tissue by tuberculosis, tumor, hemorrhage, acute infection, thrombosis or some other direct-acting agency. Investigators have also described an enlargement, loss of pigment and disappearance of the medulla of the gland in wasting diseases, particularly in diseases due to inanition and dietary deficiencies (vitamins). It is not necessary to review the mass of literature in detail, since it is summarized in the articles here cited.1
The purpose in this article is to point out a type of suprarenal insufficiency frequently seen in certain regions, which seems to be associated with definite climatic factors, and
MILLS CA. FUNCTIONAL INSUFFICIENCY OF THE SUPRARENAL GLANDS. Arch Intern Med (Chic). 1928;42(3):390–408. doi:https://doi.org/10.1001/archinte.1928.00020020078010
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