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September 1928

PERITONITISIV. PRODUCTION OF ACTIVE IMMUNITY AGAINST THE FATAL OUTCOME OF EXPERIMENTAL FECAL PERITONITIS

Arch Intern Med (Chic). 1928;42(3):415-418. doi:10.1001/archinte.1928.00020020103012
Abstract

In a previous communication,1 it was shown that active immunity can be produced in dogs against a fatal outcome following "colon bacillusgum tragacanth" peritonitis. Since one of the more common causes of peritoneal infection is soiling of the peritoneum by intestinal contents, this investigation was undertaken to determine whether active immunity can also be developed against a fatal outcome in this type of peritonitis. Since colon bacillus is found with and without other organisms in a high percentage of cases of peritonitis due to rupture of the appendix or perforation of intestines, it was determined to investigate the capacity of the colon bacillus alone to produce active immunity against the fatal outcome of fecal peritonitis.

EXPERIMENTAL METHOD AND EXPERIMENTS 

Method.  —In preliminary experiments, it was found that the intraperitoneal injection into a dog of a saline suspension of 5 Gm. of solid feces from the lower portion of the

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