In a previous communication,1 it was shown that active immunity can be produced in dogs against a fatal outcome following "colon bacillusgum tragacanth" peritonitis. Since one of the more common causes of peritoneal infection is soiling of the peritoneum by intestinal contents, this investigation was undertaken to determine whether active immunity can also be developed against a fatal outcome in this type of peritonitis. Since colon bacillus is found with and without other organisms in a high percentage of cases of peritonitis due to rupture of the appendix or perforation of intestines, it was determined to investigate the capacity of the colon bacillus alone to produce active immunity against the fatal outcome of fecal peritonitis.
EXPERIMENTAL METHOD AND EXPERIMENTS
—In preliminary experiments, it was found that the intraperitoneal injection into a dog of a saline suspension of 5 Gm. of solid feces from the lower portion of the
STEINBERG B, GOLDBLATT H. PERITONITISIV. PRODUCTION OF ACTIVE IMMUNITY AGAINST THE FATAL OUTCOME OF EXPERIMENTAL FECAL PERITONITIS. Arch Intern Med (Chic). 1928;42(3):415–418. doi:10.1001/archinte.1928.00020020103012
Customize your JAMA Network experience by selecting one or more topics from the list below.