In 1788, Cawley1 reported an intimate relationship between the sugar-regulating function and the pancreas and considered pancreatic disease an important factor in the etiology of diabetes. This was confirmed by various workers, such as Bright, Bouchardat, Friedreich, Bamberger, Frerichs, Senator, Seegen and others. The reports, however, were not more than statistical statements until Lancéraux (1877), on the basis of many clinical and anatomic observations, described a special form of diabetes called diabète pancréatique or diabète maigre. This form is characterized by a sudden onset, a malignant course and a special tendency to the complication of tuberculosis. The epoch-making discovery of von Mering and Minkowski2 in 1889, as well as the independent observations of N. de Dominicis,3 that complete extirpation of the pancreas in dogs always caused pronounced glycosuria, had made a marked effect on the development of the investigation of diabetes. Following the suggestion of Lancéraux, Bouchard and Gilbert in
OKADA S, IMAZU T, KURAMOCHI K, HORIUCHI K, TZUKAHARA T. PANCREATIC FUNCTION: II. THE PANCREATIC ACTIVITY IN DIABETES MELLITUS. Arch Intern Med (Chic). 1928;42(4):560–575. doi:10.1001/archinte.1928.00130210108010
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