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Article
November 1928

XANTHOMATOSIS AND THE RETICULOENDOTHELIAL SYSTEM: CORRELATION OF AN UNIDENTIFIED GROUP OF CASES DESCRIBED AS DEFECTS IN MEMBRANOUS BONES, EXOPHTHALMOS AND DIABETES INSIPIDUS (CHRISTIAN'S SYNDROME)

Author Affiliations

DETROIT

From the Children's Clinic.

Arch Intern Med (Chic). 1928;42(5):611-674. doi:10.1001/archinte.1928.00130220002001
Abstract
  • Pathologic

  • Considerations

  • Pathogenesis in Relation to Hyperlipoidemia and the Reticulo-Endothelial System CONTENTS

  • Introduction.

  • Report of Cases.

  • Résumé of Cases Showing Christian's Syndrome.

  • Christian's Syndrome and Xanthomatosis.

  • Historical Consideration of Xanthoma in Relation to Christian's Syndrome.

  • Constituion

  • General Account General comment of the Symptomologic considerations

  • Clinical Picture Clinical and symptomologic considerations concerning syndrome

  • Microscopic changes

  • Microscopic and clinical changes

  • Microscopic changes concerning the syndrome

  • Study of microscopic changes—conclusions

  • Pathogenic theories

  • Hypercholesterinemia

  • Hyperlipoidemia—clinical consideration

  • Hypercholesterinemia and animal experimentation

  • The reticulo-endothelial system and xanthomatosis

  • General Comment in Relation to the Syndrome.

  • Conclusions regarding pathogenesis.

  • Conditions that should be included as manifestations of a general disturbance of lipoid metabolism.

  • The nature of the nodular lesions.

  • Clinical features in general.

  • Summary and Conclusions.

INTRODUCTION  Xanthoma was first described as a rare disease of the skin. It is still classed as a dermatologic condition, although for a long time it has, in all its many

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