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November 1928


Arch Intern Med (Chic). 1928;42(5):675-702. doi:10.1001/archinte.1928.00130220066002

The object of these studies on chronic arthritis has been to correlate the bacteriology and cytology of synovial fluid with the clinical aspects of the disease. The anatomy and physiology of the cellular elements were studied by the supravital method of staining living cells. An endeavor was made to ascertain whether there is any difference between the cytologic observations in sterile synovial fluid and in that from which positive cultures of bacteria are obtained. There is no account in the literature of a correlation of these factors.

Considerable attention has been given in the literature to the bacteriologic and clinical aspects of both acute and chronic arthritis. Cytologic studies of the synovial fluid have been considered in less detail and rather inadequately. We had hoped that this would have some bearing on the cultural observations, and that a positive joint culture could be predicted from the number and types of

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