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November 1928

ROENTGEN-RAY THERAPY OF THE HYPOPHYSIS IN A PATIENT WITH ACROMEGALYITS EFFECT ON DEXTROSE TOLERANCE

Author Affiliations

SAN FRANCISCO

From the Endocrine and Metabolic Clinics of the University of California Medical School.

Arch Intern Med (Chic). 1928;42(5):703-717. doi:10.1001/archinte.1928.00130220094003
Abstract

The widespread involvement of various organs and tissues of the body in that remarkable disease, acromegaly, has been commented on by many writers. In a monograph detailing the autopsies in four cases, Cushing and Davidoff1 emphasized the protean manifestations produced by the exaggerated secretion from the anterior portion of the hypophysis. They called attention not only to the extraordinary osseous deformities and "acromegalic myxedema" which hitherto have dominated the clinical picture but also to the pronounced visceromegalies (cardiac, hepatic, renal, splenic, etc.), and to the noteworthy secondary involvement of most of the other ductless glands.

Several publications of late have dealt particularly with the carbohydrate metabolism in acromegaly (for instance, those of Cushing and Davidoff,2 Colwell,3 John4 and Ellis5). The incidence of diabetes mellitus in acromegaly has been variously estimated from 9 per cent (Arnold6) to as high as 40 per cent (Borchardt7). Cushing and Davidoff2 reported glycosurhi one out

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