When creatine is administered orally to men and animals, a portion of it may be excreted in the urine apparently unchanged, the remainder being retained by the organism. If the quantity of creatine ingested is small, as was the case in some of Folin's early experiments1 and in a recent experiment of Rose, Ellis and Helming,2 none will appear in the urine. With larger doses an appreciable quantity is excreted, but some is always retained, normally. The efficiency of the body in utilizing a given dose of creatine decreases if the administration of creatine is continued from day to day. This was clearly shown in the experiments of Benedict and Osterberg on dogs3 and in those of Chanutin4 and Rose, Ellis and Helming2 on men, in which creatinuria appeared and became more decided as the creatine feeding was persisted in. Chanutin4 has pointed out that in respect to their utilization,
CAJORI FA, WRIGHT LM, STILZ E. INGESTED CREATINE: ITS UTILIZATION AND RATE OF EXCRETION BY ARTHRITIC AND NORMAL SUBJECTS. Arch Intern Med (Chic). 1928;42(6):901–908. doi:10.1001/archinte.1928.00130230103009
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