The present day evidence, although incomplete, is in favor of the view that the bile acids are formed in the hepatic parenchyma, but what is the evidence on which this assumption is based? For many years, it was assumed that bile pigments were formed in the liver and could not be formed elsewhere. It is becoming increasingly evident that bile pigments are formed largely outside the liver and eliminated through the liver. That bile pigments are formed rapidly and abundantly in the circulation outside the liver is confirmed and extended by observations made by Mann and his collaborators,1 who employed complete extirpation of the liver and infusion of sugar in experiments lasting from twelve to eighteen hours. Is it possible that bile acids, in like fashion, may be formed outside the liver and merely eliminated by it? A discussion of these points has been made in a recent review2 and
KATAYAMA I. BILE ACIDS IN JAUNDICE. Arch Intern Med (Chic). 1928;42(6):916–930. doi:10.1001/archinte.1928.00130230118011
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